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Preclinical screens for synthetic lethality are now being performed in different model organisms, including human cells, with the aim of identifying potential targets and strategies for the …
Mar 6, 2023 · The clinical translation of the BRCA/PARP synthetic lethality, combined with the recent development of approaches based on CRISPR (see Glossary) to perform large-scale loss-of …
Jul 15, 2024 · A classic example of the use of synthetic lethality in cancer therapy is the development of poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of cancer patients carrying …
Aug 1, 2011 · The genetic interaction between PARP and BRCA can be described as synthetic lethal. Synthetic lethality between two genes occurs where individual loss of either gene is compatible with …
Jul 12, 2022 · Among the 12 high-confidence hits were 6 genes with known deleterious alterations in human tumors (Cancer Genome Atlas Research Network et al., 2013): ATM, RNASEH2A, RNASEH2B, …
Jan 1, 2013 · In this chapter, I will review the molecular mechanism for this synthetic lethality and the clinical applications for PARP inhibitors. I will also discuss the formats of synthetic lethal screens, …
May 21, 2025 · Abstract. PARP inhibitors (PARPi) are an approved class of anticancer therapeutics that inhibit the activities of PARP1/2 and produce synthetic lethality in BRCA1/2-mutated cancers …
415 In our chemogenomic screen we identified and subsequently validated multiple 416 cancer-relevant genetic alterations that profoundly sensitized cells to ATRi/PARPi 417 combinations and …
Jun 15, 2020 · RESULTS Genome-wide CRISPR screen identifies PARP14 synthetic lethal candidates In order to identify genes which are essential for cellular viability in the absence of PARP14, we …
Apr 8, 2025 · Aim To study druggable synthetically lethal gene pairs in targeted cancer therapy, which have been identified through various genetic screens and functional studies. Participants NA …
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